Due to the large number of medicinal plastic bottles, small dozens of milliliters, large thousands of milliliters, colorless, transparent, diverse colors, different shapes, and a wide variety of categories. In the face of the exciting plastic bottle market, as a pharmaceutical manufacturer, the following principles should be grasped when selecting plastic bottles:
l, select the main raw material of plastic bottles, additive formula: the product standard of solid plastic bottles, respectively stipulate the applicable main raw materials, and must meet the requirements of non-toxic, no odor, etc., due to the availability of a variety of main raw materials This requires the selection of the comprehensive properties of the raw materials. Generally, the tablets are made of high-density polyethylene and polypropylene. If the transparency is required, PET bottles are required. For example, if the drug needs higher barrier properties and is blocked or opaque, brown is used. PET bottles, better barrier properties for PEN bottles. Liquid dosage forms generally use polypropylene or polyester bottles as the main raw material.
2. Sealing property and water vapor permeability of the bottle and the cover. Sealability and water vapor permeability are two important technical indicators for pharmaceutical plastic bottles, which play an important role in the stability of the charge.
3, plastic bottle product quality standards. From the product quality standards of the production plant, the quality of the product can be analyzed and judged. Pharmaceutical plastic bottle enterprises should set enterprise standards that are stricter than national standards and industry standards.
4. Quality assurance system. Auditing suppliers has become an essential part of the procurement of plastic bottles. Through auditing, a comprehensive and correct assessment of the software and hardware facilities, technical equipment and quality level of the production plant can be made.
5. Charge stability and compatibility of plastic bottles. The selection of plastic bottles, especially new drugs using new plastic bottles (or new materials, new processes) should first carry out a charge test to examine the stability of the charge and the compatibility between the plastic bottle and the drug. The penetration, dissolution, adsorption, chemical reaction and denaturation of drugs and plastic bottles must be determined by scientific testing.